Eimear E. Kenny is a researcher in population genetics and translation genomics, and is the Founding Director of the Institute for Genomic Health, and Endowed Chair and Professor of Genomic Health at the Icahn School of Medicine at Mount Sinai. She is known for novel approaches in computational genomics, advancing the study of human genetic variation and its connection to disease risk and diagnosis. Her research has laid the foundation for integrating artificial intelligence (AI) and genomics into precision medicine and routine clinical care. By combining genomics, computer science, and medicine, her work leverages genomic sequencing technologies and machine learning algorithms to uncover insights that improve patient care, accelerate genomic data analysis, and enable the future of AI-driven healthcare. She has led multiple genomics-based clinical trials, applying computational biology and AI in clinical settings to advance genomic medicine and precision healthcare. == Research == A recipient of the Early-Career Award from the American Society of Human Genetics (USA), Kenny, as of 2024, leads a team in genetics, computer science, and medicine, focusing on genetic ancestry, large-scale genomics, clinical trials, and genomic medicine at the Institute for Genomic Health. The lab works to advance understanding of genetic ancestry and its impact on health in order to inform better clinical medicine models. She is recognized for her work to leverage biobanks for translational genomics and her development of new genetic tests an strategies for health care management. In one study, she and her colleagues investigated genetic disorders that might be under-diagnosed due to insufficient data, and found a variant in a collagen gene associated with Steel syndrome. This syndrome caused short stature and bone and joint issues and was thought to be rare. However, the study revealed it is common in individuals with Puerto Rican ancestry. Three of Kenny's genomic medicine clinical trials assessed how to bring new technology, such as digital apps, or information, such as polygenic risk scores, into routine clinical care. In the 2010s, Kenny was instrumental in several large-scale sequencing studies, including the 1000 Genomes Project, the Exome Sequencing Project, the Genome Sequencing Project, and the Trans-Omics for Precision Medicine. In 2012, she led work that discovered the variant responsible for blond hair in Melanesia, work that was featured in the Smithsonian NHGRI Human Genome Exhibit in Washington, D.C. In 2017, her group was one of the first to demonstrate that polygenic risk scores derived in predominantly European populations have reduced accuracy when applied in populations now widely acknowledged as a major challenge in the field of genomic risk prediction. As of 2024, she is Principal Investigator in many NIH-funded international consortium focused on computational genomics and genomic medicine, including Electronic Medical Records and Genomics, Polygenic Risk Methods in Diverse Populations, and the Human Pangenome Reference Consortium. In 2023, Kenny played a key role in a groundbreaking advancement in genomics research by helping to map a diverse human pangenome—a major shift from reliance on a single reference genome. Unlike the earlier genetic map, based on one man of mixed European and African ancestry in Buffalo, this new pangenome project captures far greater human genetic diversity. As reported by The Washington Post, Kenny's work demonstrates how a more inclusive human genome can drive discoveries in rare genetic diseases, improve genomic medicine, and accelerate the future of precision healthcare. Kenny was co-developer and current license holder for Random Forest adMIXture (RFMix), a patented software for inferring continental and sub-continental ancestry at genomic loci. == Education and career == Kenny graduated from Trinity College Dublin with a BA in Biochemistry in 1999 and did a masters in Bioinformatics at Leeds University. She received her PhD in Computational Genomics at Rockefeller University, and did her post-doctoral work in the lab of Dr. Carlos D. Bustamante at Stanford University. === Academic appointments === As of 2024, at Mount Sinai, she serves as the Endowed Chair and Professor of Genomic Health, Professor at the Department of Medicine and Professor at the Department of Genetics and Genomic Sciences. Since 2018 she has served as the Founding Director of the Institute for Genomic Health, and since 2022, she also serves as the Founding Director of the Center for Translational Genomics. She is also the Director of Translational Research, Division for Genomic Medicine. Former appointments include Assistant Professor at the Department of Genetics and Genomic Sciences and Member at The Charles Bronfman Institute of Personalized Medicine, both at Mount Sinai. She was also Bioinformatics Programmer at the California Institute of Technology, and research assistant at the Massachusetts Institute of Technology. == Publications == As of 2024, Kenny is an advisor to Cell Genomics. Google Scholar reports 50,623 citations, an h-index of 66 and an i10-index of 130. The five most-cited articles she contributed to are: Auton, A; Brooks, LD; Durbin, RM; Garrison, EP; Kang, HM; Korbel, JO; Marchini, JL; McCarthy, S; McVean, GA; Abecasis, GR (2015). "A global reference for human genetic variation". Nature. 526 (7571): 68–74. Bibcode:2015Natur.526...68T. doi:10.1038/nature15393. PMC 4750478. PMID 26432245.. Cited by 14847 Abecasis, GR; Auton, A; Brooks, LD; DePristo, MA; Durbin, RM; Handsaker, RE; Kang, HM; Marth, GT; McVean, GA (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65. Bibcode:2012Natur.491...56T. doi:10.1038/nature11632. PMC 3498066. PMID 23128226.. Cited by 8287 Jacob A. Tennessen et al. Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes.Science337,64–69(2012).DOI:10.1126/science.1219240 Cited by 1886 Taliun, D.; Harris, D.N.; Kessler, M.D.; et al. (2021). "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program". Nature. 590 (7845): 290–299. Bibcode:2021Natur.590..290T. doi:10.1038/s41586-021-03205-y. PMC 7875770. PMID 33568819.. Cited by 1369 Vilhjálmsson, BJ; et al. (2015). "Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores". Am J Hum Genet. 97 (4): 576–92. doi:10.1016/j.ajhg.2015.09.001. PMC 4596916. PMID 26430803.. Cited by 1327
Microsoft Support Diagnostic Tool
The Microsoft Support Diagnostic Tool (MSDT) is a legacy service in Microsoft Windows that allows Microsoft technical support agents to analyze diagnostic data remotely for troubleshooting purposes. In April 2022 it was observed to have a security vulnerability that allowed remote code execution which was being exploited to attack computers in Russia and Belarus, and later against the Tibetan government in exile. Microsoft advised a temporary workaround of disabling the MSDT by editing the Windows registry. == Use == When contacting support the user is told to run MSDT and given a unique "passkey" which they enter. They are also given an "incident number" to uniquely identify their case. The MSDT can also be run offline which will generate a .CAB file which can be uploaded from a computer with an internet connection. == Security vulnerabilities == === Follina === Follina is the name given to a remote code execution (RCE) vulnerability, a type of arbitrary code execution (ACE) exploit, in the Microsoft Support Diagnostic Tool (MSDT) which was first widely publicized on May 27, 2022, by a security research group called Nao Sec. This exploit allows a remote attacker to use a Microsoft Office document template to execute code via MSDT. This works by exploiting the ability of Microsoft Office document templates to download additional content from a remote server. If the size of the downloaded content is large enough it causes a buffer overflow allowing a payload of Powershell code to be executed without explicit notification to the user. On May 30 Microsoft issued CVE-2022-30190 with guidance that users should disable MSDT. Malicious actors have been observed exploiting the bug to attack computers in Russia and Belarus since April, and it is believed Chinese state actors had been exploiting it to attack the Tibetan government in exile based in India. Microsoft patched this vulnerability in its June 2022 patches. === DogWalk === The DogWalk vulnerability is a remote code execution (RCE) vulnerability in the Microsoft Support Diagnostic Tool (MSDT). It was first reported in January 2020, but Microsoft initially did not consider it to be a security issue. However, the vulnerability was later exploited in the wild, and Microsoft released a patch for it in August 2022. The vulnerability is caused by a path traversal vulnerability in the sdiageng.dll library. This vulnerability allows an attacker to trick a victim into opening a malicious diagcab file, which is a type of Windows cabinet file that is used to store support files. When the diagcab file is opened, it triggers the MSDT tool, which then executes the malicious code. Originally discovered by Mitja Kolsek, the DogWalk vulnerability is caused by a path traversal vulnerability in the sdiageng.dll library. This vulnerability allows an attacker to trick a victim into opening a malicious diagcab file, which is a type of Windows cabinet file that is used to store support files. When the diagcab file is opened, it triggers the MSDT tool, which then executes the malicious code. The vulnerability is exploited by creating a malicious diagcab file that contains a specially crafted path. This path contains a sequence of characters that is designed to exploit the path traversal vulnerability in the sdiageng.dll library. When the diagcab file is opened, the MSDT tool will attempt to follow the path. However, the path will contain characters that are not valid for a Windows path. This will cause the MSDT tool to crash. When the MSDT tool crashes, it will generate a memory dump. This memory dump will contain the malicious code that was executed by the MSDT tool. The attacker can then use this memory dump to extract the malicious code and execute it on their own computer. == Retirement == Microsoft will no longer be supporting the Windows legacy inbox Troubleshooters. In 2025, Microsoft will remove the MSDT platform entirely. Get Help is the replacement tool. == Windows versions == Windows 7 Windows 8.1 Windows 10 Windows 11 (up to 22H2) Future versions and feature upgrades will deprecate the MSDT after May 23, 2023.
Line detection
In image processing, line detection is an algorithm that takes a collection of n edge points and finds all the lines on which these edge points lie. The most popular line detectors are the Hough transform and convolution-based techniques. == Hough transform == The Hough transform can be used to detect lines and the output is a parametric description of the lines in an image, for example ρ = r cos(θ) + c sin(θ). If there is a line in a row and column based image space, it can be defined ρ, the distance from the origin to the line along a perpendicular to the line, and θ, the angle of the perpendicular projection from the origin to the line measured in degrees clockwise from the positive row axis. Therefore, a line in the image corresponds to a point in the Hough space. The Hough space for lines has therefore these two dimensions θ and ρ, and a line is represented by a single point corresponding to a unique set of these parameters. The Hough transform can then be implemented by choosing a set of values of ρ and θ to use. For each pixel (r, c) in the image, compute r cos(θ) + c sin(θ) for each values of θ, and place the result in the appropriate position in the (ρ, θ) array. At the end, the values of (ρ, θ) with the highest values in the array will correspond to strongest lines in the image == Convolution-based technique == In a convolution-based technique, the line detector operator consists of a convolution masks tuned to detect the presence of lines of a particular width n and a θ orientation. Here are the four convolution masks to detect horizontal, vertical, oblique (+45 degrees), and oblique (−45 degrees) lines in an image. a) Horizontal mask(R1) (b) Vertical (R3) (C) Oblique (+45 degrees)(R2) (d) Oblique (−45 degrees)(R4) In practice, masks are run over the image and the responses are combined given by the following equation: R(x, y) = max(|R1 (x, y)|, |R2 (x, y)|, |R3 (x, y)|, |R4 (x, y)|) If R(x, y) > T, then discontinuity As can be seen below, if mask is overlay on the image (horizontal line), multiply the coincident values, and sum all these results, the output will be the (convolved image). For example, (−1)(0)+(−1)(0)+(−1)(0) + (2)(1) +(2)(1)+(2)(1) + (−1)(0)+(−1)(0)+(−1)(0) = 6 pixels on the second row, second column in the (convolved image) starting from the upper left corner of the horizontal lines. page 82 == Example == These masks above are tuned for light lines against a dark background, and would give a big negative response to dark lines against a light background. == Code example == The code was used to detect only the vertical lines in an image using Matlab and the result is below. The original image is the one on the top and the result is below it. As can be seen on the picture on the right, only the vertical lines were detected
Sorenson Squeeze
Sorenson Squeeze was a software video encoding tool used to compress and convert video and audio files on Mac OS X or Windows operating systems. It was sold as a standalone tool and has also long been bundled with Avid Media Composer. == History == Sorenson Squeeze was first announced on July 17, 2001, as the first variable bit rate (VBR) compression application for Mac OS X, and was released on October 29 of that same year. By March 2002, Sorenson Squeeze became available for Windows OS. Sorenson Squeeze was originally released as a tool for encoding videos for the Web and QuickTime playback but began adding new codecs as more versions were released. The software was discontinued by Sorenson in January 2019, and correspondingly was no longer offered as part of Avid Media Composer. == Features == Squeeze included a number of features to improve video & audio quality. Features included: GPU accelerated H.264 encoding, adaptive bitrate encoding, HD encoding and Dolby certified AC3 Audio. Intelligent encoding presets available in Squeeze included: x265 (H.265) MainConcept H.264 and MainConcept H.264 CUDA. Adaptive bitrate encoding allows for optimal bitrate and error resilience based on network conditions, resulting in a dynamic adjustment of the video bitstream being delivered. It encoded to multiple formats including QuickTime, Windows Media, Flash Video, Silverlight, WebM & WMV. It uses multiple codecs, including the Sorenson codecs SV3 Pro and Spark, H.265, H.264, H.263, VP6, VC1, MPEG2, and many others. Squeeze operates on the Apple Macintosh and Microsoft Windows operating systems. Squeeze offers native plugins to Avid, Apple Final Cut Pro and Adobe Premiere (CS4, CS5) NLEs. Each copy of Squeeze included the Dolby Certified AC3 Consumer encoder. Squeeze also included a simplified review and approval process, which allows the user to automatically send secure, password protected videos for immediate review. Instant feedback is received via Web or mobile. == Versions == Sorenson Squeeze was released on October 29, 2001. Sorenson Squeeze for Macromedia Flash MX was released on March 14, 2002. Sorenson Squeeze 3 for MPEG-4 was released in January 2003. Sorenson Squeeze 3 Compression Suite was released in January 2003. Sorenson Squeeze 5 was released on March 31, 2008. Sorenson Squeeze was updated to version 5.1 on May 11, 2009. Sorenson Squeeze 6 was released on November 3, 2009. Sorenson Squeeze 7 was released January 25, 2011. Sorenson Squeeze 11 was released August 27, 2016. == Awards == Streaming Media magazine Readers’ Choice Award for Encoding Software for 2007, 2008, 2009 and 2010. 2008 Vanguard Award from Digital Content Producer magazine == Squeeze 7 system requirements == Windows Pentium IV-based computer or greater Windows XP, Vista or 7 32- and 64-bit compatible (including AVID 64-bit update); Faster performance on 64-bit systems 512 MB RAM 120 MB available hard drive space QuickTime 7.2 or later DirectX 9.0b or later Macintosh Intel-based processor Mac OS 10.4 or later 32- and 64-bit compatible; Faster performance on 64-bit systems 512 MB RAM 120 MB available hard drive space QuickTime 7.2 or later
Agent-assisted automation
Agent-assisted automation is a type of call center technology that automates elements of what the call center agent 1) does with his/her desktop tools and/or 2) says to customers during the call using pre-recorded audio. It is a relatively new category of call center technology that shows promise in improving call center productivity and compliance. == Types of agent-assisted automation == === Pre-recorded audio === Pre-recorded audio (sometimes referred to as soundboard (computer program) or as soundboard technology) is another form of agent-assisted automation. The purpose of using pre-recorded messages is to increase the probability (and in some cases error-proof the process so) that the right information is provided to customers at the right time. The required disclosures are pre-recorded to ensure accuracy and understandability. By integrating the recordings with the customer relationship management software, the right combination of disclosures can be played based on the combination of goods and services the customer purchased. The integration with the customer relationship management software also ensures that the order cannot be submitted until the disclosures are played, essentially error-proofing (poka-yoke) the process of ensuring the customer gets all the required consumer protection information. Phone surveys are ideal applications of this technology. Whether surveying market preferences or political views, the pre-recorded audio with an agent listening allows the questions to be asked in the same way every time, uninfluenced by the agents' fatigue levels, accents, or their own views. === Fraud prevention === Fraud prevention is a specialized type of agent-assisted automation focused on reducing ID theft and credit card fraud. ID theft and credit card fraud are huge threats for call centers and their customers and few good solutions exist, but new agent-assisted automation solutions are producing promising results. The technology allows the agents to remain on the phone while the customers use their phone key pads to enter the information. The tones are masked and the information passes directly into the customer relationship management system or payment gateway in the case of credit card transactions. The automation essentially makes it impossible for call center agents and also call center personnel that might be monitoring the calls to steal the credit card number, social security number, or other personally identifiable information. === Outbound telemarketing === Another specialized application space of agent-assisted automation is in outbound telemarketing, which goes under numerous headings including outbound prospecting, cold calling, solicitation, fund-raising, etc. Turnover is high among agents engaged in this kind of work because the task is tedious and emotionally difficult. It is tedious because the agent spends the bulk of their day, not talking to qualified leads, but in getting wrong numbers and answering machines. == Benefits == Just as automation has benefited manufacturing by reducing the mental and physical effort required of workers while simultaneously improving throughput, quality, and safety, agent-assisted automation is improving call center results while reducing the tiring aspects of the job for agents. In some cases, the agent-assisted automation streamlines the process and allows calls to be handled more quickly. By eliminating cutting and pasting from one application to another, by auto-navigating applications, and by providing a single view of the customer, agent-assisted automation can reduce call handle time and increase agent productivity. Second, in theory, the more steps that can be automated and the more logic that can be built into the call flow (e.g., if the customer buys items 2 and 9, then disclosures a, c, and f are read by the pre-recorded audio), then companies may be able to reduce the amount of training that is required of the agents while at the same time ensuring more consistency and accuracy. However, no published studies have reported this result yet. But an even larger problem in call centers is between-agent variation in behavior and results. Agents differ in the amount of training and coaching they receive, they differ in the amount of experience they have, their jobs are repetitious and tiring, and the process and procedures the agents are supposed to follow constantly change. Moreover, there are significant individual differences between agents in their intelligence, personality, motivations, etc. which all affect performance. Despite the large amount of money call centers have spent over decades trying to reduce between-agent variation, the problem is still so prevalent that one large study of customer interactions with call centers found that a customer's experience was completely a function of the quality of the agent who happened to answer the phone. Therefore, the most significant benefit of agent-assisted automation may prove to be in how the automation error-proofs or poka-yoke the process and ensures that something that needs to be done or said happens every time. Properly implemented, the between-agent variation for whatever step of the process the automation is applied to may be able to be reduced to near zero. This is especially important in a collection agency whose processes and procedures are closely regulated by the Fair Debt Collection Practices Act.
Simple interactive object extraction
Simple interactive object extraction (SIOX) is an algorithm for extracting foreground objects from color images and videos with very little user interaction. It has been implemented as "foreground selection" tool in the GIMP (since version 2.3.3), as part of the tracer tool in Inkscape (since 0.44pre3), and as function in ImageJ and Fiji (plug-in). Experimental implementations were also reported for Blender and Krita. Although the algorithm was originally designed for videos, virtually all implementations use SIOX primarily for still image segmentation. In fact, it is often said to be the current de facto standard for this task in the open-source world. Initially, a free hand selection tool is used to specify the region of interest. It must contain all foreground objects to extract and as few background as possible. The pixels outside the region of interest form the sure background while the inner region define a superset of the foreground, i.e. the unknown region. A so-called foreground brush is then used to mark representative foreground regions. The algorithm outputs a selection mask. The selection can be refined by either adding further foreground markings or by adding background markings using the background brush. Technically, the algorithm performs the following steps: Create a set of representative colors for sure foreground and sure background, the so-called color signatures. Assign all image points to foreground or background by a weighted nearest neighbor search in the color signatures. Apply some standard image processing operations like erode, dilate, and blur to remove artifacts. Find the connected foreground components that are either large enough or marked by the user. For video segmentation the sure background and sure foreground regions are learned from motion statistics. SIOX also features tools that allow sub-pixel accurate refinement of edges and high texture areas, the so-called "detail refinement brushes". As with all segmentation algorithms, there are always pictures where the algorithm does not yield perfect results. The most critical drawback of SIOX is the color dependence. Although many photos are well-separable by color, the algorithm cannot deal with camouflage. If the foreground and background share many identical shades of similar colors, the algorithm might give a result with parts missing or incorrectly classified foreground. SIOX performs about equally well on different benchmarks compared to graph-based segmentation methods, such as Grabcut. SIOX is, however, more noise robust and can therefore also be used for the segmentation of videos. Graph-based segmentation methods search for a minimum cut and therefore tend to not perform optimally with complex structures. The algorithm has initially been developed at the department of computer science at Freie Universitaet Berlin. The main developer, Gerald Friedland, is now faculty at the EECS department of the University of California at Berkeley and also a Principal Data Scientist at Lawrence Livermore National Lab. He continues to support the development through mentoring, e.g. in the Google Summer of Code.
Advanced automation functions
In automation production technology the actions performed by an automated process are executed by a program of instructions which is run during a work cycle. To execute work cycle programs, an automated system should be available to execute these advanced functions. == Safety monitoring == If there is a need for workers in an automated system, a safety monitoring is required for the occupational safety and health of the workers. In a safety monitoring various steps can take place including a complete stop of the system, sounding an alarm or reducing the operating speed. Usually, limiting switches are sensors like temperature probes, heat and smoke detectors or pressure sensitive floor pads. == Maintenance and repair diagnostics == There are three modes of operations which are used in a cycle of maintenance and repair diagnostics: status monitoring, failure diagnostics and recommendation of the repair procedure. In the status monitoring mode, the current system status is displayed. The failure diagnostics mode takes place when a failure occurs. The system will then suggest an adequate repair procedure to a team of experts. == Error detection and recovery == The error detection mode is a step to determine if and when a failure occurs in automated system. The possible errors can be divided into three categories. random errors, systematic errors and aberrations. While in the error recovery mode, remedy actions take place for all detected errors.